منابع مشابه
Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.
To detect viral infections and tumors, CD8+ T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are generated from the cleavage of cellular and viral proteins by the ubiquitin-proteasome pathway. Many of the oligopeptides produced by this process are too long to stably bind to MHC class I molecules and...
متن کاملTrimming of antigenic peptides in an early secretory compartment
Major histocompatibility complex (MHC) class I molecules bind peptides of 8-10 residues in the endoplasmic reticulum (ER) and convey them to the cell surface for inspection by CD8-expressing T cells (TCD8+). Antigenic peptides are predominantly derived from a cytosolic pool of polypeptides. The proteolytic generation of peptides from polypeptides clearly begins in the cytosol, but it is uncerta...
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T he function of the p53 tumor suppressor protein is finely tuned through a myriad of interactions with other proteins. These interactions can lead to posttranslational modifications that regulate p53 stability, DNA binding, or promoterspecific transcriptional activation. A number of p53 binding proteins serve as cofactors that participate in the recruitment of p53 to specific promoters and fac...
متن کاملTrimming for subdivision surfaces
Trimming is an important primitive operation in geometric modeling. It is also the root of many numerical and topological problems in modern NURBS based CAGD systems. In this paper we introduce a new method for trimming subdivision surfaces. It is based on the use of combined subdivision schemes to guarantee exact interpolation of trim curves. The latter ensures, for example, that if two surfac...
متن کاملAntigen presentation: Peptides and proteins scramble for the exit
The fate of peptides that fail to bind to major histocompatibility complex class I molecules in the endoplasmic reticulum (ER)has remained unclear. A recent study has revealed that these peptides exit the ER via the Sec61 channel and compete for this pathway with misfolded proteins.
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2006
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1765